This game going to have weapons or any nature of combat?

[Romulator]

So, what if you can ATTEMPT to fight back, but it will be either alltogether unsuccesfull, resulting in you being killed, or it will hinder your enemy for max of several seconds (the blow of the wrench throwed him\it off the balance for example), but otherwise didn't affected the enemy at all, and he is still after you, but that attack can possibly get you out of tight situations when you are cornered and nowhere to run or hide.

*throws box at Grunt*
1. Grunt shakes it off like Taylor Swift, then comes charging, resulting in more powerful hit.
2. Box pushes grunt slightly. Doesn't stutter. Chases you.

Amnesia and Penumbra have had their methods of halting/limiting enemy encounters and taking damage using pretty much what you described. Considering that's the same direction Frictional Games has taken in the past, and the fact we haven't seen any weapons which could attack enemies lethally and be held by the player, honest speculation is no. There won't be weapons. But there will be objects to stun enemies unless they are unable to be stunned.