Plotwise, can Brutes be killed?

[Froge]

I've always wondered: how brutal is the average Brute? We already know that grunts are indeed, quite gruntish, as evidenced by the one that got totally chopped up in the sewers. Gabriel's Remember story also notes that the Grunt can feel pain and be burned to death. So really, if you have a gun with you, Grunts aren't something to worry about.

But the brutality of the Brute has never truly been ascertained, because not once in the game or in the Remember stories does it die traditionally; getting crushed by the shadow or falling down an Abyss doesn't count. Assume a simple one-on-one battle between a Brute and a human, where the human could use any weapon of their choice. How powerful would this weapon have to be in order to kill the Brute? Do you think it can realistically die by a weapon?