Trackball Mouse is failing to click on certain things in game.

[Romulator]

Well, the first thing I can ask for you is to determine if your trackball mouse drivers are up to date by checking with the manufacturer's website. If they are not, then that would be the first thing to try and fix.

Have you perhaps tried playing at a lower resolution or in windowed mode if you're not doing so already?

If neither of these help, then I recommend posting the hpl.log file, as stated at Problem X of the Troubleshooting guide here: https://www.frictionalgames.com/forum/thread-30585.html It can give us an idea of your system and other generic settings you are using in SOMA.