Please check the troubleshooting guides before posting!

[Mudbill]

It depends on what kind of speaker configuration you have. If you use headphones, set it to headphones. If you use a dual speaker setup, set it to 2 speakers. The 5.1 speaker setting you won't need to worry about if you don't know what it is. If you have a 5.1 speaker setup, you'd know. Basically those include multiple surround outputs and a subwoofer.

Unless I'm remembering the settings wrong I guess this is it.

Edit: I wasn't able to find a speaker setting. Which one are you talking about?