Penumbra Overture Glitch, Maybe?

[EpiqueSauce]

Could be that you need to run a cache integrity check on the game in steam, then when you start the game again load a saved game from before the first time you entered the room with the pistons.

I did that, and had the same problem.
What I did and finally made it through, was jump around the buttons, whilst clicking like a mad man. gg.