Would it be possible?

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I thought about it for a while, but ships are quite small compared to a castle or your usual Amnesia settings. Perhaps it would have to be a story about the ship visiting separate places and the experiences along the way and/or at each place.

...naah...the small size and simplicity of the environment is the beauty of it! I mean if you can make an interesting full-length movie that plays entirely in a single Phone Booth, surely you can make an intersting story on a ship, right? That's what I meant with restrictions fueling ones creativity!

I think it could create a very striking atmosphere - a ghost ship, silently floating in the middle of a dead calm, surrounded by thick fog that slowly creeps closer and closer... and whatever it is that's killed the crew, it's on there with you and your only escape would be to drown in the cold, dark ocean. Having the ship move somewhere else would just kill that atmosphere imo