Problem: "Could not load main init file: config/main_init.cfg"

[Urkle]

kataare, Can you try going into your "~/Library/Application Support/Frictional Games/Amnesia/Main" folder and look at the sizes of the .cfg files contained there.

If any of them are 0 bytes.. Please delete them and see if that fixes the issue. Last resort is to simply rename the entire Main folder to Main.bak and try running the game again. (You can copy your saved games from within your profile over so you don't lose your progress if it fixes the issue)