Well, making mod with me3 style is hard. But in my current project, I have implemented player choice system. Player can choose what to answer. Right now as much I have done, it doesn't really change anything what follows, but it does influence person he talks with how he responds. For example if you talk with okay dude, but you are jerk, you will get way less answers then if you are nice. It could be opposite to jerk person tho. You might need to use also jerky attitude to get some answers. But it overall doesnt affect THAT MUCH, but this is just right now
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