*Possible spoilers for both games and TV episode in this topic*
I've just started watching the series (it's on Netflix), and the episode "Ice" in season 1.
http://en.wikipedia.org/wiki/Ice_%28The_X-Files%29
It's set in an arctic research station where extra-terrestrial Worms (found by drilling into the frozen surface) invade their hosts and drive them into a blind killing spree. Even if you guys have never seen this episode, I thought it was an interesting and cool little episode. The premise immediately reminded me of Black Plague. Even if this X-Files episode itself took a lot of inspiration from "The Thing" lol.
I hope in no way do you guys (Frictional) think I am insulting your integrity! I'm just pointing out a cool little relation between the two!