I cannot save

[plutomaniac]

Ok, it is good that you haven't updated the game in the middle of it. Are you sure though cause steam autoupdates the game. If you have retail then it is ok. When you load the game and you are not where you supposed to be, can you check whether things that you did were saved? For example do this now:

Load the game
Do something like reading a note, take an object
Save and exit
Load the game and go see if these are gone

This is to check whether the game really does save instead of ignoring you.