Game freezes during insanity; can't do anything but force shutdown.

[plutomaniac]

That is a computer-specific issue. Maybe the graphics or sound drivers are old. Or maybe something in the background is causing problems. Or maybe your game files are corrupted. Do a steam file integrity check (reinstall from scratch if no steam) and try resetting game settings (A3). After the problem occurs attach HPL.log as mentioned at the Troubleshooting Guide which I assume you have already read carefully.